Grace often proves to be pushy, obnoxious, clingy and self-idolizing, to the point where even her news crew wishes for her death. Despite Xander's attitude toward her, Grace remains fanatically devoted to him, even freezing some of his semen without his knowledge, which she later uses to impregnate herself.
During an attempt to interview Killface on top of the Annihilatrix a battle breaks out causing her to get knocked off and fall into "drums full of super-intelligent, radioactive waste covered ants". Shortly after, the ants inhabit her brain and she develops a split personality with super powers. She had no control over the switch and no memory of the change when she returns to her normal self, though she realizes what is going on when she finds stolen money and jewelry in her house. Her super-side calls herself Antagone. She has the relative strength of ants and can spit an eye blinding acid. Throughout Xander's campaign she remained clingy to him, even after he left her for dead in his plunging campaign jet, in hopes that she could become his potential first lady.
In episode 21 "The Debate part 2" she is suddenly pregnant and was going to ask him to marry her but as usual Xander pays little attention and asks her why she is such a fattie and tells her she "can't has cheeseburger" when she says she has something to ask him. Following the debate she seems to have become Antagone full-time and is bent on killing Crews. She joins Sinn, Val, and Watley as part of a new super villain group called the Sisterhood of Chaos. This frail organization quickly crumbles due to the inability to get along with each other.
In episode 2-11, Antagone gives birth to her child which is mutant baby that is growing at an ever increasing rate. Her elation at it's birth is short lived, however, when the baby bites her head off within seconds of being born.